Third Biome
Biome Balance New
A foundational daily postbiotic built to reach your colon intact and work from dose one, repairing the gut lining, fuelling the cells that line it, and calming the signals that keep digestion unpredictable.
- Repairs the gut lining & tightens tight junctions
- Fuels colonocytes, your colon's lining cells
- No colonising required, no guesswork
- Vegetarian capsules (HPMC Capsule)
Gut repair takes a season. A subscription keeps the protocol going at 20% off, ships free, and you can skip or cancel anytime, most members feel the first shift by week two.
In our registered, randomised, double-blinded RCT (CTRI/2025/09/094597), the GTB arm raised stool butyrate by 74% over 45 days, with IBS-SSS and GSRS symptom scores significantly improving alongside.
One to two capsules daily with water, any time of day, with or without food. Consistency matters more than timing, take it at the same moment each day to build the habit.
Thirdbiome GTB™ (micro-encapsulated glyceryl tributyrate) 500 mg. Vegetarian capsule (HPMC). Made in a US FDA-registered, WHO-GMP facility.
One capsule. Three jobs.
Butyrate is the compound a healthy gut makes for itself. Biome Balance delivers it directly, so it goes to work on the gut lining from the very first dose.
The raw material for tight-junction repair, sealing the gaps behind "leaky gut" so the barrier between gut and bloodstream holds.
Colonocytes draw ~70% of their energy from butyrate. Fed, the lining regenerates faster and digestion steadies.
Dials down inflammatory signalling (TNF-α) in the gut wall, easing the gas, urgency and unpredictability of a worn-down lining.
Most gut actives don't survive stomach acid, GTB™ does.
Registered, double-blinded RCT · 45 days · CTRI/2025/09/094597
A pH-targeted shell shields GTB™ from stomach acid through the digestive tract.
Releases butyrate at the colon, exactly where your gut lining needs it most.
One ingredient. Nothing to hide.
Most gut supplements hide behind a "proprietary blend" of a dozen strains at doses no one discloses.
Biome Balance is the opposite: a single, named, proprietary active at a defined 500 mg, the finished end-metabolite, not a bacteria count you have to take on faith. If it's on the label, you can look it up.
Simple to take. A season to reward you.
Gut repair compounds over weeks, not days. Here's what one capsule a day actually looks like, and when to expect the shift.
Works on arrival
Unlike a probiotic, there's no colony to establish. The compound is active the moment it reaches your colon.
Gas & bloating ease
The most common first signal. Digestion starts to feel lighter and more predictable through the day.
Steadier, clearer
Nine in ten members notice a shift by week two, calmer digestion, fewer crashes, sharper focus.
The repair pays off
Lining repair compounds over a season. Most members choose to keep the protocol going, which is why we recommend three months.
Why not just take a probiotic?
Probiotics send live bacteria and hope they survive, colonise, and behave. A postbiotic skips the gamble, it's the finished metabolite, delivered intact.
Registered, double-blinded RCT · 45 days · CTRI/2025/09/094597. Real-world figures from T3B Club 30-day cohorts · self-reported.
What it did for them.
All cases are single-participant, self-reported, and do not establish causality.
4.8 from 212 verified members
“The bloating eased in the first week, and the brain fog lifted by mid-afternoon.”
“They show the actual trial and its limits. That honesty is what sold me.”
“One capsule, no 12-step routine. My digestion is finally predictable.”
Before you start
No, it's a postbiotic, the finished metabolite (butyrate, via GTB™) your gut would normally make for itself. No live cultures to keep alive or hope will colonise.
Most people feel gas and bloating ease within the first week or two. Gut-brain and systemic benefits build over the season, months, not days.
If you're pregnant, nursing, on medication, or managing a condition, check with your doctor first.